Heart problems are a big deal, causing millions of deaths every year. One major issue is atherosclerosis, where bad cholesterol builds up in arteries, forming plaques. This happens because of oxidized LDL, a harmful molecule that triggers inflammation. Current treatments focus on lowering cholesterol and controlling blood pressure, but they don't always tackle the in...
Triple-negative breast cancer (TNBC) is tough to tackle due to issues like poor blood vessels and high tumor cell load. These problems make it hard for CAR-T cells, a type of immune cell therapy, to work well. Researchers found that when there are fewer CAR-T cells compared to tumor cells, the immune response isn't as strong. They also discovered that problems with c...
Scientists have been using lentiviral vectors (LV) to transfer genes into T cells, including those used for chimeric antigen receptor (CAR) T cell therapy. While this method has been successful, there's still room for improvement. Researchers studied how human T lymphocytes react to different types of LVs and found that certain genes linked to cell inactivity and ant...