AI Teams Up with Temperature to Enhance Proteins

Designing proteins that are both stable and effective can be a real challenge for scientists. But what if AI could step in and simplify this task? Introducing PRIME, an AI model that harnesses temperature to predict optimal protein modifications. During testing with a variety of proteins, PRIME outperformed other top models. Scientists tested it on five different proteins, focusing on the top 30-45 individual changes. They looked at factors like how well the proteins tolerated heat, their ability to bind with antibodies, and their resistance under tough conditions. Surprise, surprise! PRIME's suggestions were better than the original proteins in over 30% of cases. Not only that, PRIME can quickly find combinations of changes that boost both protein activity and stability. This AI model could revolutionize the way proteins are engineered, making the process more efficient and effective. But is it a true game-changer? Time will tell as PRIME continues to be tested and refined.