SCIENCE

AI's Glowing Protein: Nature's Eons in Hours

Thu Jan 30 2025
A protein that shines bright like a jellyfish but was not crafted by Mother Nature. Scientists have done the impossible, creating a glowing protein using AI. This protein, esmGFP, was not born from millions of years of evolution. It was dreamt up by AI in a matter of hours. The AI, known as ESM3, learned from a vast collection of known proteins. It didn't evolve like life on Earth, but used patterns to create something entirely new. The result? A glowing protein with a structure only 58 percent similar to any natural counterpart. Scientists have long used glowing proteins to make other proteins visible. From a glowing jellyfish to a glowing cancer cell. These glowing proteins have been a big deal in science for years. The AI coded 96 mutations that would take over 500 million years to naturally arise. This means the AI can make proteins that nature would never come up with! Some experts are excited, others skeptical. Evolving biology is complex and requires a diversity of interactions. Some scientists think that AI models like ESM3 might not capture these nuances. But others are convinced that this AI could unlock amazing possibilities. This could range from new medicines to proteins that capture carbon. Think about the implications of this. We can now create proteins that do not exist. This could change medicine, environmental science, and more. Scientists can use these new proteins to study cancer, capture carbon, and more. But we still need to be careful. Evolution is a complex process, and we should tread lightly as we explore this new frontier. This breakthrough raises big questions. Can AI really understand biology as well as nature does? What might be the consequences of our AI-designed proteins? It's a good reminder that with great power comes great responsibility. Scientists have created an artificial protein that glows in the dark. It's a major leap in biology and technology. They have opened the doors of possibility to new medicines and environmental solutions. But we must be cautious, as evolution is complex and we must respect nature's rules. Proteins are the building blocks of life. They are made up of amino acids and folded into complex shapes. These shapes determine what the protein does. By using AI, scientists can create proteins with new shapes and functions. This is a milestone. AI can now mimic and accelerate evolution. It can create proteins that nature would never come up with. But it's also a warning. We must be cautious as we explore this new frontier.

questions

    Is there a hidden agenda behind the rapid advancements in AI protein design, and who might be benefiting from it?
    How does the AI model ESM3 ensure that the generated proteins are stable and functional in real-world applications?
    What are the potential ethical implications of accelerating protein evolution through AI, and how can they be addressed?

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