Brain Network Changes in Recovered Depression

Depression messes with your brain’s communication highways, or networks. Scientists have found three main networks that go haywire during depression: the default mode network (DMN), central executive network (CEN), and salience network (SN). These networks help us think, feel, and pay attention. When people are recovering from depression (rMDD), scientists wanted to know if these networks still have trouble chatting with each other. They looked at how well these networks talked to each other while people were resting and when they were doing a task that made them think and feel at the same time, called the emotional Stroop task. Surprisingly, they found that the DMN network talked more to itself during the task. But the CEN and SN networks talked less to each other and themselves. This was even more noticeable in people recovering from depression. Additionally, the rMDD group had better chatter between the DMN and SN, and the CEN and SN. The researchers also found that people who thought a lot about their problems (ruminated) had less network talk time during rest. But those who tried to solve their problems had more network talk time while doing the task. This means that tasks that make us think and feel can change how our brain networks talk to each other, especially in people recovering from depression. This might show that our brains are trying to protect themselves and find new ways to work. But more research is needed to make sure these findings are true.