SCIENCE

Building Better Sperm: A New Way to Study Spermatogenesis

Tokyo, JapanSat Jan 04 2025
Trying to figure out how to make healthy sperm in a lab. This isn't easy because spermatogenesis, the process of making sperm, is super complex. It's also the main reason why some men can't have kids. Scientists have been looking for a good way to mimic this process in the lab using animal testes. One method they've tried is growing mouse and rat testes in a gel, but it has some problems. The gel soaks up the nutrients and makes it hard to see what's happening. So, scientists came up with a new idea. They sandwiched the testes between two special materials: a porous plastic on top and a gas-permeable plastic at the bottom. This setup kept the testes happy for months and let the researchers watch the sperm develop. They even got healthy baby mice from the lab-made sperm! This new method can help us understand how sperm are made and might even help find better ways to treat male infertility.

questions

    How does the new device compare to other in vitro spermatogenesis models in terms of efficiency and simplicity?
    What are the practical implications of the membrane ceiling method for clinical treatments of male infertility?
    What are the potential biases in the results due to the use of transgenically fluorescent sperm?

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