Can Alzheimer's Really Be Reversed?

Being diagnosed with a disease that once seemed unbeatable, only to find that simple lifestyle changes could reverse its devastating effects. Meet Cici Zerbe and Simon Nicholls, two individuals who claim to have conquered Alzheimer's through healthy habits. Their remarkable stories have sparked hope and questions about the true potential of lifestyle modifications in fighting this debilitating disease. The numbers are staggering. In the UK, dementia and Alzheimer's have been the leading causes of death for the past decade, accounting for 11. 4% of all deaths in 2022. While new treatments can slow down the progression of the disease, experts are increasingly convinced that a healthy lifestyle can play a significant role in "reversing" symptoms. But what does "reversing" even mean in the context of Alzheimer's? The disease can be categorized into two subgroups: familial and sporadic. Only 5% of patients have the familial type, which is inherited, while 95% are affected by the sporadic type, which is linked to environmental, lifestyle, and genetic risk factors. This highlights the need for a preventative approach, focusing on healthy habits to reduce the risk of developing the disease in the first place. Zerbe's journey began with a clinical trial in the US, which explores the effects of intensive lifestyle changes on mild cognitive impairment or early dementia due to Alzheimer's. The study, which has not yet been published, involves a plant-based diet, regular exercise, group support sessions, yoga, and meditation. Zerbe claims she feels "much better" than when she was diagnosed five years ago and has experienced a reversal of symptoms. Simon Nicholls, also featured in the CNN documentary, has an even more remarkable story. With two copies of the ApoE4 gene variant, which significantly increases the risk of Alzheimer's, he was expected to suffer from the disease. However, after adopting a healthy lifestyle, his biomarkers for Alzheimer's disappeared in just 14 months – a feat more effective than most treatments. Nicholls credits physical activity and dietary changes for his success. He incorporated strength training, walking, jogging, and cycling, while also removing sugar, alcohol, and processed foods from his diet. He adopted the Mediterranean diet, rich in antioxidants that protect brain cells from damage and research suggests can maintain memory and cognitive skills. A recent study found that adhering to a Mediterranean diet decreases the risk of dementia by 23%. However, we must exercise caution when interpreting these findings. These are individual cases, and more research is needed to fully understand the impact of lifestyle changes on Alzheimer's. Even so, the potential benefits are undeniable. By combining new disease-modifying drugs with strict lifestyle changes, scientists hope to significantly reduce symptoms and the progression of Alzheimer's.