Chicken's brains and immune system: An unexpected connection

Chickens might not seem like the most interesting subjects for scientific research, but recent findings throw light on a hidden world inside their bodies. When it comes to chickens, the pineal gland is a small but vital part of the brain. This tiny gland produces key chemicals that includes indoles like melatonin, neurosteroids, and catecholamines. Taken to another level, when you put a chicken through an infection like peritonitis, it gives a big clue on their health and givess a better look into their pineal gland. The gland's activity shifts dramatically when chicks that hatched in the summer get an infection. This is where the story takes a surprising twist. Researchers took a deep dive. First, they looked at the levels of melatonin and its partners. Then, they checked out chemicals like noradrenaline and dopamine. The researchers also counted the genes that help the brain talk to itself and the genes that make up the immune system. To test this, researchers induced peritonitis by injecting thioglycollate into chickens. 4 hours came and gone,they took samples of the pineal gland and blood. Guess what they found? 5-HTP, N-acetylserotonin, melatonin (MEL), 5-hydroxytryptophol, and L-DOPA levels went through the roof, but serotonin, dopamine, and noradrenaline levels dropped. The genes involved in the immune response also became more active. Genes like interleukin-1β (IL-1β), interleukin-18 (IL-1β), TLR4, and interleukin-6 receptor showed increased expression. Also, something interesting happened. Researchers saw that the immune system's activation affects the pineal gland in a seasonal or cyclic pattern. They also found that the immune system and the brain's chemical production are closely linked. It gives an idea of the metabolic cost, and how the body balances its resources when dealing with infections and life. This suggests that our brains chemicals aren't as simple as we thought, and they might be more affected by our immune system than we realized.