HEALTH

Choosing the Right Antidepressant: A Balancing Act

United Kingdom, UKWed Oct 22 2025

Researchers have ranked the side effects of different antidepressants, highlighting that some can cause weight gain, while others might affect heart rate or blood pressure.

Key Findings

  • Weight Changes:
  • Agomelatine: Can lead to weight loss
  • Maprotiline: Can cause weight gain

  • Heart Rate Effects:
  • Some antidepressants slow down the heart rate
  • Others speed it up

  • Blood Pressure Considerations:
  • Venlafaxine and nortriptyline: Not suitable for people with high blood pressure

Personalized Treatment

  • SSRIs: Tend to have fewer physical side effects
  • Importance of Matching: The best antidepressant for one person might not be the best for another
  • Most prescriptions in the UK are for:
  • Citalopram
  • Sertraline
  • Fluoxetine

Future Implications

  • Researchers are developing an online tool to help doctors and patients choose the right drug
  • More research is needed to understand the long-term impacts

questions

    What are the ethical implications of matching antidepressants to individual needs versus prescribing the most commonly used drugs?
    Is it possible that some antidepressants are just trying too hard, like that one friend who always brings too much drama?
    Is the development of a free online tool for choosing antidepressants a way to collect and monetize patient data?

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