Decoding NF-κB: A Key Player in Cancer and Immunity

NF-κB, a crucial player in cell functions, has been under the spotlight since its discovery. It's like a conductor in the orchestra of our cells, directing immune responses, inflammation, and cell survival. When it goes haywire, it can lead to various diseases, especially cancer. This review dives into the NF-κB family and their signaling pathways. It's like a complex game of telephone, where the message changes based on the context. In the tumor environment, NF-κB is a bit of a troublemaker, helping cancer cells grow, spread, and hide from the immune system. There are drugs targeting NF-κB, some already approved by the FDA, others still in development. New strategies are also emerging, like delivering drugs straight to the tumor, combining treatments, and using nanotechnology. The future looks promising, with a focus on understanding NF-κB better, improving treatments, and personalizing therapies. Artificial intelligence is also stepping into the scene, offering hope for faster discoveries and tailored treatments. In the end, NF-κB modulation seems to be a versatile and promising approach for tackling cancer and immune diseases.