Exploring How Chemo Changes Immune Cells in Lung Cancer

Chemotherapy is a common treatment for lung adenocarcinoma, but it has its limitations. So, scientists are looking into how it affects our body's defense system. They studied cells from nine patients who either had surgery or chemotherapy before surgery. They found that chemotherapy changes how immune cells like macrophages and T cells behave. In simple words, there are two types of macrophages: Anti-mac cells that fight tumors, and Pro-mac cells that help tumors grow. After chemotherapy, Pro-mac cells increased. These cells promote tumor growth and keep the immune system from attacking the tumor. But, chemotherapy also boosts the immune system's attack on tumor cells. So, it's a mix of good and bad effects. The scientists hope their findings will help understand why some lung cancers become resistant to drugs and find new treatment targets.