Exploring MSM in Horses: A Study on Elimination Times and Limits

Did you know that even plants and animals can sometimes use a compound called methylsulfonylmethane (MSM), also known as dimethyl sulfone? This naturally occurring substance is part of our world, but when it comes to horseracing, it's a bit controversial. Both MSM and its relative dimethyl sulfoxide (DMSO) are banned due to their anti-inflammatory and pain-relieving effects. The International Federation of Horseracing Authorities has set limits for MSM and DMSO in horse urine, which are 1200 and 15 micrograms per milliliter, respectively. A recent study decided to find out how MSM behaves in horses. Two geldings were given a scoop (about 15 grams) of Pure MSM twice a day for six days. Their urine and blood were then tested to see how much MSM remained. Using gas chromatography-mass spectrometry, researchers discovered that MSM could be detected in urine for about 4. 5 days after the last dose, at the set International Residue Limit (IRL) of 1200 micrograms per milliliter. In blood samples, MSM levels reached around 120 micrograms per milliliter on the same day, suggesting that this could be a potential limit to control MSM in horse blood. A surprising find was that DMSO didn't seem to be a significant product of MSM's breakdown in horses. This insight could help in better understanding how these substances work in different species.