How Fat Cells Fuel Aggressive Breast Cancer

Triple-negative breast cancer (TNBC) is notoriously difficult to treat. Unlike other types of breast cancer, it doesn't respond well to common therapies. But why? Recent research points to an unexpected culprit: fat cells nearby.

The Role of Fat Cells

Normally, fat cells store energy. However, in TNBC, they undergo significant changes. They lose fat and become inflamed, sending signals to cancer cells that promote growth and spread.

Key Signals: ANGPTL4 and KLF4

Scientists have identified two critical signals: ANGPTL4 and KLF4. These signals cause cancer cells to use more sugar, providing them with the energy they need to grow and spread rapidly—like giving a car more fuel to drive faster.

How Fat Cells Change

The interaction between fat cells and cancer cells alters the behavior of the fat cells. While the exact details remain unclear, it's evident that fat cells play a significant role in TNBC progression.

Implications for Treatment

This research highlights that fat cells are not merely passive bystanders. They can actively contribute to cancer growth. Understanding these signals could lead to new treatment strategies, potentially targeting these pathways to stop cancer in its tracks.