How Klebsiella pneumoniae Outsmarts Antibiotics

Klebsiella pneumoniae, a sneaky germ found worldwide, is getting tougher to treat. Scientists tested how well antibiotics work on some clinical samples and a reference strain, ATCC13883. They looked at what genes were active and found some interesting things. A particular sample, DY16KPN, seems to fight back by building up important parts of its cell, like fats, proteins, and DNA. It also seems to make less stuff move in and out of its cell. Another thing it does is make more of a substance called butanoate and some sugar-like stuff on its surface, which might also help it resist drugs. Scientists also spotted changes in certain gene promoters, which control other drug-resistant genes and pathways. When it comes to trimethoprim/sulfamethoxazole, this germ boosts the activity of certain enzymes to counteract the drug's effect on making DNA building blocks.