How Lymphocyte Immunotherapy Affects Fertility in Women with Recurrent Pregnancy Loss

You're trying to have a baby but keep losing pregnancies. Doctors call this recurrent pregnancy loss (RPL). Some women with RPL have antinuclear antibodies (ANA) in their blood. Scientists wanted to see if a treatment called lymphocyte immunotherapy (LIT) could help these women. They studied 84 women with ANA, 114 without ANA, and 50 healthy pregnant women. They used special tools to count and measure certain cells and chemicals in the blood. Before LIT, healthy pregnant women had fewer natural killer (NK) cells and fewer pro-inflammatory chemicals than women with RPL. After LIT, the number of NK cells and some chemicals changed, especially in women without ANA. Women who got routine treatment didn't see these changes. The study found that LIT helped women with RPL have more pregnancies that lasted and resulted in live births, especially those without ANA.