HEALTH

Hunting Cancer with Smart Antibodies

Tue Jul 22 2025

Cancer is a sneaky foe, but scientists are fighting back with clever tools. One such tool is a special kind of antibody designed to target multiple myeloma, a type of blood cancer. These antibodies are like smart missiles, programmed to seek out and attack cancer cells.

How They Work

The antibodies are engineered to recognize a protein called CD38. This protein is found in high amounts on the surface of multiple myeloma cells. By targeting CD38, the antibodies can zero in on the cancer cells and help the body's immune system fight them off.

The Dual Action

But here's where it gets even smarter: These antibodies are not just single-target weapons. They are bispecific, meaning they can recognize and bind to two different proteins at once. In this case, they target:

  • CD38 on the cancer cells
  • CD28 on immune cells

This dual action can boost the immune system's response, making the attack on the cancer cells even more effective.

Advancements and Challenges

The development of these bispecific antibodies represents a significant advancement in cancer treatment. They offer a more precise and potentially more effective way to target and destroy cancer cells. However, like any new treatment, there are challenges and potential side effects that need to be carefully managed.

The Future of Cancer Treatment

Researchers are continuing to explore and refine this approach. The goal is to make these treatments even more effective and safer for patients. The journey to find a cure for cancer is long and complex, but every new tool like this brings hope for better outcomes.

questions

    Will the antibodies get tired of their job and go on strike, leaving the myeloma cells to party uncontrollably?
    Can bispecific anti-CD38/CD28 antibodies be used in combination with other treatments, and if so, what are the benefits and drawbacks?
    Are pharmaceutical companies pushing bispecific anti-CD38/CD28 antibodies to make more profit, even if there are better treatments out there?

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