Exploring New Sugar-Based UV Filters: A Sunscreen Breakthrough

Cinnamic acid sugar esters, or CASEDs, are natural compounds known for their various biological benefits. But have you ever thought about using them in sunscreen? A recent study dived into this idea, creating a bunch of new cinnamic acid esters using glucose, ribose, and lactose. These compounds were made from specific acetals, which were obtained by a process called oxidative alkoxycarbonylation of olefins. Scientists checked out the UV-Vis spectra and lipophilicity (how well they dissolve in fat) of these compounds. They also tested their cytotoxicity, which is basically how harmful they are to cells. Most of these new compounds were found to be non-cytotoxic, meaning they didn't harm cells at the concentrations tested. The absorption spectra depended on the substituents (the extra groups attached to the main structure) on the aromatic ring.The star of the show was compound 3k, which had a 4-methoxy group on the phenyl ring and a 1, 2-O-isopropylidene ribose moiety. This compound showed great potential as a sunscreen ingredient. Its Sun Protection Factor (SPF), calculated in a lab setting, was higher than that of ethylhexyl methoxycinnamate (EHMC), which is already used in sun care products. Plus, it had better antioxidant properties, protecting skin cells from oxidative damage caused by hydrogen peroxide. But that's not all! Compound 3k didn't show any cytotoxic effects and kept the cells' metabolic activity and protein content intact. These findings suggest that CASEDs could be a game-changer in the skincare and cosmetics industry.