How Adrenergic Receptors Influence Sweating During Exercise

Ever wondered how your body keeps you cool while you exercise? Scientists have been looking into how certain receptors, called α- and β-adrenergic receptors, help regulate sweating, especially when you're working out in the heat. They found that blocking these receptors can affect how much you sweat. In one study, researchers had young adults do a 30-minute moderate exercise routine. They also gave them drugs that targeted these adrenergic receptors. The drugs were applied to the forearm skin using a method called iontophoresis. They found that when they blocked the β-adrenergic receptors, sweat rates changed too. Adding a α-adrenergic blocker made the sweat rates even less.Another part of the study involved giving people adrenaline-like drugs (epinephrine and norepinephrine) to see how they affected sweating. Again, blocking the β-adrenergic receptors changed the sweat rates, but this time, adding the α-adrenergic blocker changed it less. From all this, the scientists concluded that α-adrenergic receptors mainly control how much you sweat during exercise. The β-adrenergic receptors, on the other hand, didn't seem to play a big role in exercise sweating. And one drug, called bretylium, which stops sympathetic nerves from working, likely reduces sweating in a different way entirely.