How AKG and OXGR1 Team Up for Healthier Sperm

Ever wondered how your body helps sperm become strong and ready for their job? Deep inside the epididymis, which is like a training camp for sperm, lies a special receptor called OXGR1. As we age or face heat stress, OXGR1 levels drop, which can mess up sperm growth. But don't worry, a natural helper called α-ketoglutaric acid (AKG) comes to the rescue. When AKG talks to OXGR1, it triggers a tiny burst of calcium inside the cells. This calcium helps control the acid-base balance in the fluid surrounding the sperm, making it just right for them to mature.Scientists found that adding more AKG can fix some of the problems caused by aging and heat stress. Not only that, AKG also encourages cells to make more of a protein named NBCe1, which further balances the acid-base levels. So, when you think about fertility, keep in mind the dynamic duo of OXGR1 and AKG. They work together, behind the scenes, to ensure sperm can do their important job correctly.