Simple Chemistry for Powerful Antioxidants

Scientists have found a new way to make special molecules called quinazolinones. These molecules are important because they can fight harmful substances in the body called free radicals. The new method is special because it doesn't use any metals and is easy to do. Instead of using complicated tools, they used a common substance called polyethylene glycol 200, or PEG-200, to help the reaction happen. The process is gentle and works well, creating many different types of quinazolinones. Some of these molecules are very good at protecting cells from damage. Two of them, in particular, stood out. One is called (4-(trifluoromethyl) phenyl) quinazolin-4(3H)-one, and the other is 6-chloro-2-phenylquinazolin-4(3H)-one. These two were the best at neutralizing harmful free radicals.To understand how this works, the scientists used a method called density functional theory. This helps them see how the molecules change during the reaction. The new method is not only good for making these molecules but also for finding ones that can be used in medicine. This discovery is exciting because it shows a simple way to make useful molecules. It could lead to new treatments and products that help people stay healthy. The best part is that this method is easy and doesn't require expensive or complicated equipment.