Targeting Lipid Uptake and Synthesis for Better Prostate Cancer Treatment

Prostate cancer (PCa) often becomes resistant to treatment, making it hard to cure. This type of cancer is linked to unusual lipid metabolism, which makes it tough to treat. Scientists have come up with a clever way to tackle this problem. They designed a tiny nanomachine called HA@CD36i-TR@siSCD1. This little wonder blocks two important parts of lipid metabolism in PCa: uptake and synthesis. The nanomachine has a smart shell that releases drugs in response to the cancer's acidic environment and an enzyme called hyaluronidase.Its core releases drugs when it detects glutathione. This dual response helps to effectively stop lipid uptake and production. The nanomachine shows great promise, as it can slow down the growth, spread, and movement of PCa. Even better, it works well in high-fat conditions, boosting the body's immune response against the cancer. This breakthrough offers a new hope for people with tough-to-treat PCa, especially those who follow a high-fat diet.