The Changing Role of Astrocyte Mitochondria: A New Angle on Neuronal Injury

Did you know that astrocytes, often seen as the support crew in the brain, have a surprising role in neuronal injury? In Uruguay, research on these glial cells has a long history, dating back almost to the birth of the Uruguayan Society for Neuroscience. Astrocytes, traditionally known for their supportive roles in the central nervous system, transform dramatically when neurons get hurt. This transformation, called glial reactivity, changes the shape and function of these cells. Now, astrocytes are not just the brain's housekeepers. They are heavily involved in the brain's energy demands, making metabolic support crucial for neurons. Astrocytes have a dense network of mitochondria, the cell's powerhouses. These mitochondria can shift in shape and activity during glial reactivity.Here’s where things get interesting. Even though these mitochondria in astrocytes are often overlooked, recent studies show they play a big part in diseases like amyotrophic lateral sclerosis. By activating these mitochondria, damage in neurodegenerative diseases can be reduced. Scientists are now looking at how astrocytes' metabolism changes after damage, making them shift into a new state. This shift affects how diseases progress. Understanding how mitochondria behave in these cells could help in creating new ways to treat neuronal damage.