The Power of Hertia Leaves: A Natural Weapon Against Obesity

For ages, people have used the leaves of the Hertia cheirifolia L. plant to treat various health issues like hemorrhoids, diarrhea, and stomachaches. Scientists have now found a new use for these leaves: helping fight obesity. They extracted the aerial parts of the plant using hexane after hydroalcoholic maceration. This resulted in a crude extract that was analyzed using GC-MS, revealing 34 different compounds.One compound, ligularenolide, stood out. It showed promising cytotoxicity without any signs of causing cancer or heart problems. Other compounds, however, had moderate enzyme inhibition but higher toxicity levels. The stability of the ligularenolide-human pancreatic lipase (HPL) complex was highlighted in dynamic studies, suggesting its potential as an anti-obesity agent. Ligularenolide was found to significantly inhibit HPL, with predictions showing it could be better than orlistat, a common anti-obesity drug. This was confirmed through PASS predictions and docking results. These findings suggest that Hertia cheirifolia L. extract could be a natural source of anti-obesity agents. More research is needed to explore its therapeutic benefits.