Understanding Breast Cancer: The Role of Deubiquitinating Enzymes

Breast cancer is one of the most common cancers among women, and it comes in many different forms. This makes it tricky to diagnose and treat. One important process in our cells is called ubiquitination, which helps regulate many things like the cell cycle, DNA repair, and more. Deubiquitinating enzymes, or DUBs, can undo this process. When these DUBs are not working properly, they can play a part in diseases like cancer.Scientists looked at public datasets of breast cancer and used special tools to find DUBs that were acting differently in breast cancer. They found six genes (COPS5, EIF3H, MINDY1, MINDY2, PSMD14, and USP26) that were significantly different and had important effects on survival. They also did experiments to check these findings. Using qPCR analysis, they found that COPS5, EIF3H, and MINDY1 were more active in MCF-7 and T47D breast cancer cells. To understand how these genes might affect the disease, they looked at how they interact with other genes that are linked to metastasis, which is when cancer spreads. They built a network to show these interactions and checked how the genes' activity levels matched up in breast cancer patients. This study gives us a better look at how DUBs behave in breast cancer. It could help find new ways to treat the disease.