Lung Cancer's Secret Path to the Adrenal Glands

Scientists took a deep dive into the genes of lung adenocarcinoma patients with adrenal metastases. They found that certain gene mutations, like TP53, EGFR, and KRAS, were common in both groups. But here's where it gets interesting: some unique gene changes, called rare variants, were more common in patients whose cancer hadn't spread to the adrenal glands. These variants might protect against adrenal metastases. On the other hand, other gene mutations, like ALK and KRAS, were linked to a poorer outlook for patients with adrenal metastases.This study also showed that patients without EGFR mutations should keep a closer eye on adrenal metastases, and those with ALK or KRAS mutations might need more aggressive treatment. Some specific cell signals, like TNF and TGF-β, seemed to play a role in how lung cancer spreads to the adrenal glands.