Malaria Mysteries: The Spleen's Role in WWII Soldiers' Relapses

During World War II, soldiers from Allied countries like the U. S. , U. K. , Australia, and India faced an unexpected challenge: frequent malaria relapses caused by Plasmodium vivax. Even with preventive medicine like quinacrine, they experienced multiple bouts of illness after stopping treatment. It was later found that those with smaller spleens were more likely to have these recurrences.Scientists have a few theories about why this happened. One is that smaller spleens might filter out infected blood cells more strictly, preventing relapses from becoming obvious. Another idea is that a small spleen could be a sign of weaker immune system, making relapses more likely. It's also possible that smaller spleens don't remove certain triggers that wake up dormant parasites. Understanding how the spleen affects these relapses can help in the fight against malaria. It shows a complex relationship between the parasite and the body, which could be used to eliminate malaria.