Meet the Enzyme That Helps Leishmania Change Shape

Ever heard of Leishmania? It's a parasite that lives in both bugs and mammals, including humans. One of its secrets to survival is an enzyme called LmexNAT10. This enzyme is crucial for the parasite's ability to change forms and multiply. It's found in the nucleus and seems to be essential for the parasite's life. When scientists tried to create a version of Leishmania without this enzyme, they couldn't do it, showing how important it is.Without LmexNAT10, the parasite has trouble changing from one form to another, especially when it's inside a bug called Lutzomyia longipalpis. This enzyme also affects how quickly the parasite multiplies and how it progresses through its life cycle. It might be doing this by changing the levels of a modification on RNA called ac4C, which is known to impact stability and translation of messages in human cells.