Mixing It Up: How to Make Ivermectin and Praziquantel Tablets with Different Release Speeds

Ever wondered how to make tablets that release their medicine at different speeds? Scientists did just that with Ivermectin (IVER) and Praziquantel (PRAZ), two key drugs for animal health. They mixed up some granules that looked similar but worked differently. They used a special machine called a high shear granulator to blend the ingredients, added water or a special mix to form tiny clumps, and then dried these clumps in a fluid bed. After that, they ground the clumps into different sizes using a cone mill and sorted them using a vibratory sieve shaker.The result? Four types of granules with different release speeds. When these granules were turned into tablets, they released their medicine at different rates. Isn't that cool? The key here is understanding how to control the release speed of medicine in tablets, which could help in making generic versions of these drugs.