New Hope for Kidney Disease: The Promise of ARNIs

ARNIs, or Angiotensin Receptor-Neprilysin Inhibitors, are making waves in the medical world. They're already changing the game for heart failure patients. Now, doctors are wondering if they can do the same for people with kidney disease. Neprilysin is a substance in the body. It breaks down certain proteins. When ARNIs block neprilysin, they might help kidneys work better. This is what early studies suggest. They show that ARNIs can reduce protein in the urine, which is a good sign. They might also help with kidney scarring and blood vessel function.But what about real-world results? So far, studies on heart failure patients show that ARNIs are safe for the kidneys. They might even have some benefits. One study, UK HARP-III, found that ARNIs can reduce protein in the urine. However, it didn't show a clear protective effect on the kidneys. This could be because the study wasn't designed to look for that. Real-world data is more promising. It shows that ARNIs have an acceptable safety profile. This is similar to other kidney disease treatments. The benefits seem to outweigh the risks. So, ARNIs could be a new option for kidney disease patients, especially those with both heart and kidney problems. But there's still more to learn. More studies are needed to figure out the best way to use ARNIs for kidney disease. Until then, they remain a promising but not yet fully proven treatment.