New Pain Solution for Surgeries: A Phase 3 Trial

Having an operation and waking up with less pain and needing fewer strong painkillers. That's what VVZ-149, a new type of pain-blocking drug, aims to do. This small molecule targets two key components in our pain system – the glycine transporter type 2 and the serotonin receptor 5-HT2A. Researchers wanted to find out if VVZ-149 could be a safe and effective single-dose injection for people who have just had a laparoscopic colectomy – a type of abdominal surgery. They conducted a Phase 3 study, which is the final step before a drug can hit the market. Scientists first ensured the drug was working as expected by checking if it reduced pain scores. They found that subjects who received VVZ-149 had lower pain levels compared to those given a placebo. Next, they looked at opioid consumption. Opioids are strong painkillers often used after surgery. Patients who got VVZ-149 needed fewer opioids to manage their pain. Safety was also a major concern. Researchers closely monitored any side effects. They found that VVZ-149 was generally well-tolerated, with no major issues. This study offers hope for a better post-surgery experience. But it's not the final word. More research and real-world use will tell if VVZ-149 lives up to its promise.