Running Downhill: Does It Boost Cancer-Fighting Proteins?

This: you’re running downhill, muscles working hard, and you wonder if this rigorous exercise could help boost proteins that fight cancer. That’s exactly what scientists set out to test. They looked at a protein called C1q, which helps activate the body’s immune response against cancer cells. The idea was that intense exercise could increase C1q in the blood, making cancer-fighting drugs more effective. To figure this out, a group of young men ran on a treadmill – once on a flat surface and once downhill. Blood samples were taken before, right after, and up to four days later. The scientists measured C1q levels and checked how well two common cancer drugs, rituximab and daratumumab, worked against cancer cells in the lab. The results? Running downhill didn’t change C1q levels or how well the drugs worked. But the downhill run did cause more muscle soreness and a temporary spike in inflammation and muscle damage markers. This suggests some muscle damage happened. Perhaps any increase in C1q was hidden by the body’s response to that damage. This was the first time anyone checked if exercise could boost C1q and help cancer drugs work better. The takeaway? Downhill running didn’t do the trick this time. But who knows what future research might uncover!