Running Helps Fight Early Alzheimer's Symptoms

Early signs of Alzheimer's often include anxiety and depression. Scientists found that a protein called SIRT1 in the hippocampus, a brain region crucial for learning and memory, plays a role in these symptoms. Research shows that exercise can boost mental health in various conditions, like stress and trauma. This study aimed to see if treadmill exercise could improve anxiety and depression in mice with Alzheimer's genes (APP/PS1 mice) and figure out how it works. The study revealed that running on a treadmill did, indeed, reduce anxiety and depression-like behaviors in the mice. They explored how this happens and discovered that it involves the SIRT1 signaling pathway in the hippocampus. This suggests that exercise might help manage the emotional symptoms of Alzheimer's. It's important to note that while these findings are promising, more research is needed to fully understand the effects of exercise on Alzheimer's symptoms in humans.