Seizure Control: A New Implant Combines Quick Zaps and Slow-Release Drugs

Epilepsy is a tough nut to crack. Doctors often use meds or deep brain stimulation to tackle seizures, but these methods have their limits. Some people don't respond well to meds, and seizures can be unpredictable. Recently, scientists have come up with new ways to tackle these challenges, like responsive neural stimulation and on-demand drug release. However, there's still a gap to fill. Electrical stimulation works fast but doesn't last long, while medication takes time to kick in. Enter the Bimodal Closed-loop Neurostimulation Implant System. This clever device combines real-time neural recording, quick electrical stimulation, and slow-release drugs to better control seizures. It's like having a tiny, smart guardian inside your brain that can zap seizures instantly and release drugs for long-term support. Scientists tested this system in mice with epilepsy. They found that the electrical zaps quickly stopped seizures, halting 75. 16% of them within seconds. And the drug release kicked in about 15 minutes later, providing additional control. This dual approach helped stabilize brain activity and reduced seizure recurrence. The best part? The system doesn't harm brain cells. After testing, scientists found no significant changes in the neurons' shape or signal quality. This means the system offers a safe, minimally invasive way to manage seizures. By bridging the gap between quick electrical effects and slower drug action, this new system presents an exciting approach to epilepsy management.