Small Molecules from Microbes Fight Back Against Colorectal Cancer

Colorectal cancer is a tricky enemy, with mutations in proteins like APC and AXIN boosting the Wnt/β-catenin pathway. The Wnt/β-catenin pathway is a key player in tumor growth and spreading. The pathway can be turned on in an unwanted way, leading to a buildup of β-catenin. This buildup is caused by problems with a process called ubiquitination, which usually keeps β-catenin in check. To tackle this, researchers are exploring a new approach that involves targeting a specific protein called Tankyrase and β-catenin itself. Some plants and microbes have unique chemicals that can potentially treat cancer. These compounds can be more precise and less toxic than traditional medications. They can be more effective than synthetic drugs. So, researchers used a computer-based screening process to sift through a massive library of 27, 641 microbial metabolites. The goal was to find the best candidates to fight cancer. This process narrowed down the list to 2, 527 potential compounds. Researchers then used advanced computer simulations to identify the most promising candidates. They focused on two key molecules: Terreustoxin I (T1) and 10-phenyl-