The Absorption Game: Why AA-I is Deadlier

Ever heard of aristolochic acids (AA)? They're sneaky compounds that can cause big problems, like chronic renal disease, worldwide. The main troublemaker is aristolochic acid I (AA-I). Scientists wanted to know why AA-I is so much worse than its cousin, aristolochic acid II (AA-II), even though they look a lot alike.They did some experiments with human cells and gut sacs. Guess what? AA-I gets absorbed better than AA-II, about three times more (that's not good). Plus, AA-I causes more DNA damage and oxidative stress. So, even though they're similar, AA-I is way more dangerous. Why the difference? It's all about how our body takes in these acids. AA-I gets in faster, and that's what makes it so toxic. In fact, having AA-II around can even make AA-I worse. Future research should focus on how to slow down the absorption of both these acids to reduce health risks.