SCIENCE
The Impact of Ketone Ester on High-Altitude Performance and Brain Function
Sat May 03 2025
In the world of sports and fitness, athletes often look for ways to boost their performance. One such method is the use of ketone esters. These are supplements that can change how the body uses energy. However, recent studies have shown that these esters might not be as helpful as some people think, especially when it comes to high-intensity exercise at high altitudes.
The main issue is that high altitudes have less oxygen. This lack of oxygen can make it harder to exercise and think clearly. Ketone esters were thought to help with this problem. They were believed to make the body more efficient at using oxygen. But, the results from a study are not so clear-cut.
In this study, 13 healthy men were tested at a simulated altitude of 4, 000 meters. They were given either ketone esters or a placebo. The results showed that those who took the esters had a 3. 6% decrease in their power output during high-intensity exercise. This means they were not able to perform as well as those who did not take the esters.
Interestingly, the esters did not affect their brain function or how much oxygen was in their blood. This suggests that the esters might not be as helpful as previously thought. They also did not increase the levels of a hormone called erythropoietin, which is important for making red blood cells. This hormone usually increases after exercise, but the esters did not seem to make a difference.
The study also found that the esters lowered the blood's pH levels, which can affect how the body works. This could be another reason why the esters did not help with exercise performance. However, the esters did not affect how the brain functioned, which is a good thing. This means that even if the esters do not help with exercise, they might still be useful for other things.
It is important to note that this study was done at a simulated altitude of 4, 000 meters. This is not as high as some other studies, which were done at altitudes of around 6, 100 meters. It is possible that the esters might be more helpful at higher altitudes. However, more research is needed to know for sure.
In conclusion, ketone esters might not be the magic solution that some people think. They might not help with high-intensity exercise at high altitudes. However, they do not seem to affect brain function, which is a good thing. More research is needed to fully understand how these esters work and if they are useful for athletes.
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questions
If ketone esters make you perform worse, should we start calling them 'lazy esters'?
How does the impairment of exercise performance by ketone esters in normoxia compare to their effects in hypoxic conditions?
What are the long-term effects of ketone ester ingestion on athletic performance and overall health?
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