SCIENCE

The Power of Two-Photon Polymerization: Biomedical Breakthroughs

Wed Jan 29 2025
Two-photon polymerization, or TPP, is a fascinating manufacturing technique gaining traction in the biomedical field. Unlike other methods, TPP can create 3D structures with incredible precision, down to the nanometer scale. What makes TPP so special is its ability to provide free-form fabrication. This means it can produce complex shapes without the need for molds or casts. Plus, the availability of ready-to-use commercial systems has made TPP more accessible than ever. In the world of biomedical applications, TPP is making waves. Its unique features have benefited a wide range of fields. From creating tiny medical devices to fashioning intricate scaffolds for tissue engineering, TPP's versatility is unmatched. Another cool aspect of TPP is the ability to both write and read 3D structures. The "writing" process involves using laser light to shape the polymer. The "reading" process, which involves characterizing the structures, influences the accuracy of both in situ and ex situ methods. Understanding how to read these structures properly is crucial for ensuring their quality and functionality. Machine learning is also getting involved in the TPP game. Scientists are using it to better control the TPP process, making it even more efficient and reliable. While TPP holds a lot of promise, there are also challenges to overcome. Current limitations need to be addressed, and there are exciting opportunities on the horizon for this emerging technology in biomedical applications.