Thyroid Cancer's Hidden Energy: ISG15 and ISGylation

This: a tiny protein called ISG15 is influencing how aggressive a type of thyroid cancer, called anaplastic thyroid carcinoma (ATC), can be. This cancer is known for its rapid growth and has a very high mortality rate. Now, scientists have discovered that ISG15 can actually change the behavior of cancer cells, making them more like cancer stem cells. These special cells can self-renew and produce different types of cancer cells, driving tumor growth. But how does ISG15 do this? The process is called ISGylation. It's like a secret language that ISG15 uses to modify other proteins inside the cancer cells. By doing so, it can control what these cells do. In ATC, ISG15 seems to make these cells more aggressive and capable of spreading.Interestingly, this protein is usually associated with helping the body fight viruses. So, why is it helping cancer cells in ATC? This is a big question that researchers are trying to answer. Maybe it's because ATC cells have found a way to hijack this system for their own advantage. Understanding this process could lead to new ways to treat ATC. If we can block ISG15 or ISGylation, we might be able to slow down or even stop these cancer cells from being so dangerous. So, next time you hear about cancer research, remember that even the tiniest proteins can have a huge impact.