HEALTH

Unraveling the Secrets of Aging and Colorectal Cancer

Thu Jul 10 2025

Colorectal cancer (CRC) primarily affects older adults. Scientists have been investigating cellular aging using DNA methylation (DNAm), a process that reveals the biological age of cells, distinct from chronological age.

The Paradox of Tumor DNAm Age

Surprisingly, tumor tissues exhibit a lower DNAm age, suggesting that cancer cells may revert to a more primitive, stem-cell-like state. However, this doesn't yet confirm DNAm as a definitive predictor of cancer.

Exploring Pre-Diagnostic Blood Samples

Researchers are now examining pre-diagnostic blood samples to determine if DNAm age can provide insights into CRC development. This could revolutionize our understanding and prevention of CRC.

Lifestyle Factors and DNAm Age

Lifestyle choices—such as diet, exercise, and habits—influence DNAm age and may impact CRC risk. Though complex, each discovery brings us closer to a comprehensive understanding.

Toward Better CRC Prevention Strategies

The ultimate goal is to leverage this knowledge to develop better prevention strategies. By understanding cellular aging and lifestyle influences, we can make informed decisions to safeguard our health.

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questions

    What confounding factors might influence the association between epigenetic aging and colorectal cancer risk?
    Do our cells age faster when we forget to take our vitamins, or is that just a myth?
    How can the ethical implications of using epigenetic markers for cancer prediction be addressed in clinical practice?

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