Why Your Meds Might Not Be Working: The Surprising Role of Your Environment

Your environment isn't just about where you live. It's also about the air you breathe, the food you eat, and the people you interact with. These factors play a huge role in shaping who you are and how well your medications work. Your genes might determine your physical traits, but your environment influences your health and personality. Things like your diet, exercise, and even the pollution you're exposed to can have a bigger impact on your health than your genes. Scientists are now studying something called exposomics. This is the study of all the environmental factors that affect your biology. Unlike your genome, which is just your genes, your exposome includes everything from the chemicals in your environment to your social interactions. Medications don't always work as expected. Sometimes, it takes months or even years to find the right treatment. For example, controlling blood pressure or treating depression can be a long process. This is where your environment comes into play. Things like grapefruit juice can interfere with how your body processes medications. The chemicals in your environment can interact with your medications in unexpected ways. For instance, chemicals from engine exhaust or burning wood can interfere with how your body processes drugs. Even chemicals used to keep fleas and ticks off pets can affect how your body breaks down medications.Researchers are using advanced tools to measure these environmental factors. They use mass spectrometers to detect thousands of chemicals in your body at once. This helps them understand how your environment might be interfering with your medications. Scientists are developing methods to measure all the chemicals in your body. They're working on a project called IndiPHARM. This project aims to measure drugs, drug metabolites, and environmental chemicals all at once. By combining environmental data with genetic information, scientists hope to improve how drugs work for people. The goal is to figure out whether chemicals in your environment or diet are altering how you process a given drug. This could lead to better prescriptions tailored to your specific needs. For example, if a drug isn't working, doctors could adjust the dose, switch to a different medication, or even redesign the medicine. The team is focusing on metabolic diseases like obesity and diabetes, along with conditions like hypertension, high cholesterol, and depression. These conditions can be tricky to treat because people respond to medications differently. By understanding these differences, scientists hope to provide tailored treatments for everyone. In the future, doctors might use your genetic and environmental history to figure out the best drug treatment for you from the start. This could reduce the need for trial and error and help you get the right medication faster.