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Jan 29 2025SCIENCE

Exploring Extreme Creatures for Medical Breakthroughs

Scientists typically focus on a few model animals like lab mice or fruit flies for medical research. But plants and other critters living in harsh environments might hold keys to solving tough health problems. Field studies of these wild animals are rare due to funding issues. Yet, understanding how

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Jan 29 2025SCIENCE

The Search for New Anti-Inflammatory Drugs: A Closer Look at P2Y14 Receptor Antagonists

Inflammation is a big deal, and it's involved in many diseases that affect people worldwide. One specific receptor, called P2Y14, plays a crucial role in these inflammatory responses. Scientists have been working on new drugs to block this receptor and reduce inflammation. They used a process called

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Jan 29 2025SCIENCE

Unraveling the Human Default Mode Network: A Closer Look at Its Structure

The default mode network (DMN) plays a crucial role in complex thinking and behavior. Scientists studied brain tissue from deceased individuals and used advanced brain imaging to understand the DMN's structure and function. They discovered that the DMN has diverse brain cell types, specialized for d

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Jan 29 2025SCIENCE

Unraveling Hidden Forces: How Big Substituents Affect Protonated Pyridines

Scientists have been digging into how big substituents, like those bulky tert-butyl groups, interact with each other in protonated pyridines. They used cool techniques like infrared multiphoton dissociation spectroscopy and trapped ion mobility spectrometry to check out these ions in the gas phase.

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Jan 29 2025SCIENCE

How Drugs Change Cancer Cell Metabolism

Drugs don't always stop cancer cells from growing, but they often mess with their metabolism. Scientists used a high-tech method, called metabolomics, to see how 1, 520 drugs affected 2, 269 potential metabolites in A549 lung cancer cells. Even though only 26% of the drugs slowed down cell growth, a

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Jan 29 2025SCIENCE

Unlocking the Power of Fish Cells: How Salmonids Break Down Pollutants

Have you ever wondered how fish deal with chemicals in their environment? Scientists have been exploring this by studying fish cells in the lab. They looked at how well these cells can break down, or biotransform, harmful pollutants. They used two systems: small parts of cells from brown trout and r

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Jan 29 2025SCIENCE

Straightening Out ETH: The Clear Path

You might have heard of the Eigenstate Thermalization Hypothesis (ETH), but scientists have been having a tough time explaining it. The problem? They mix up things that are random and things that are predictable. This can get confusing, right? So, why not focus on what we can predict? This new way o

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Jan 29 2025SCIENCE

Whispers of Japan: The Secret of Sound Hiding

Ever pondered how one noise can hide another? Enter the realm of sound masking, where Japan has been silently leading the way. This method is vital in pure tone audiometry, a critical test for hearing. Japanese researchers have been exploring this deeply, even creating mathematical models to underst

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Jan 29 2025SCIENCE

Exploring Molecular Building Blocks: How Urea-Functionalized Acetylenes Self-Assemble

Scientists have been exploring a group of molecules called urea-functionalized acetylenes, which have a constant H-bonding unit and varying hydrophobic units. These molecules are fascinating because they can self-assemble into intricate structures due to non-covalent interactions. The study found th

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Jan 29 2025SCIENCE

The Power of Two-Photon Polymerization: Biomedical Breakthroughs

Two-photon polymerization, or TPP, is a fascinating manufacturing technique gaining traction in the biomedical field. Unlike other methods, TPP can create 3D structures with incredible precision, down to the nanometer scale. What makes TPP so special is its ability to provide free-form fabrication.

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