P16
Mammalian protein found in humans
Summary
p16, is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. It is encoded by the CDKN2A gene. A deletion in this gene can result in insufficient or non-functional p16, accelerating the cell cycle and resulting in several different types of cancer.
Originally created by Dr Aaron
11/1/2006, 7:16:41 AM
Modified
4/20/2026, 5:40:52 AM
Recent revisions
[[Wikipedia:OABOT|Open access bot]]: doi updated in citation with #oabot.
/* p16 */ Copy edit ▸ Diction ▸ Suggested, fits better.
Move 1 url. [[User:GreenC/WaybackMedic_2.5|Wayback Medic 2.5]] per [[WP:URLREQ#nih.gov]]
[[Wikipedia:OABOT|Open access bot]]: url-access updated in citation with #oabot.
/* Regulation */ link
/* p16 immunochemistry */ +Positivity
[[MOS:CAPFRAG]], dash style ([[MOS:DASH]])
Changing [[Wikipedia:Short description|short description]] from "Mammalian protein found in Homo sapiens" to "Mammalian protein found in humans"
Added the cs1 style template to denote Vancouver ("vanc") citation style, because references contain "vauthors" attribute to specify the list of authors. Added bibcode. | [[:en:WP:UCB|Use this tool]]. [[:en:WP:DBUG|Report bugs]]. | #UCB_Gadget
[[Wikipedia:OABOT|Open access bot]]: hdl updated in citation with #oabot.
[[Wikipedia:OABOT|Open access bot]]: doi, hdl updated in citation with #oabot.
link [gG]ermline mutation
Clean up spacing errors around ref tags., replaced: /ref>H → /ref> H
Alter: journal. Add: doi, date, s2cid, hdl. | [[:en:WP:UCB|Use this bot]]. [[:en:WP:DBUG|Report bugs]]. | Suggested by Boghog | #UCB_webform
consistent citation formatting
/* Role in carcinogenesis */ updated with new data
[[Wikipedia:OABOT|Open access bot]]: doi added to citation with #oabot.
/* Gynecologic cancers */Sentence case for sub-section header
Importing Wikidata [[Wikipedia:Short description|short description]]: "Mammalian protein found in Homo sapiens" ([[Wikipedia:Shortdesc helper|Shortdesc helper]])
