Imagine trying to build something with a material that keeps shrinking. That's a big problem in tissue engineering. Scientists have been using collagen-based hydrogels, which are great for growing cells, but they have a nasty habit of shrinking when cells interact with them. This makes it hard to create stable structures for things like drug testing or even growing new organs.

Enter a new type of hydrogel. This one is a mix of gallic acid-functionalized hyaluronic acid, collagen I, and hyaluronic acid-coated multiwall carbon nanotubes. It's a mouthful, but it's a game-changer. This new hydrogel can be easily injected and printed in 3D, and it doesn't shrink much when cells are added. In fact, it only shrinks about 20% compared to the usual 90% with regular collagen hydrogels.

The new hydrogel is also stronger and can stick better to tissues. Plus, it can protect cells from harmful radicals. This means it could be really useful for growing heart cells and even printing functional heart ventricles. The heart cells grown in this hydrogel behave just like they would in a natural environment, which is a big plus.

The hydrogel is also great for growing other types of cells, like those derived from stem cells. This makes it a versatile tool for tissue engineering. The new hydrogel is a big step forward in creating stable, functional tissues for various applications. It's a solution to a long-standing problem in the field.

This breakthrough isn't just about creating better materials for tissue engineering. It's about making sure that the materials we use are reliable and can be used in a variety of ways. The new hydrogel is a great example of how science can solve problems and create new possibilities.

BIOFABRICATION TECHNIQUES

Building Better Tissues: The Shrink-Resistant Hydrogel Breakthrough

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