Exercise is generally beneficial, but going overboard can have negative consequences. When people engage in intense physical activity, it can disrupt their body's natural rhythm and alter brain chemistry. This disruption can lead to increased fatigue and decreased performance.

The body operates on a natural cycle known as the circadian rhythm. A crucial component of this rhythm is REV-ERB-α, which enhances muscle function during exercise. However, excessive exercise weakens this component, leading to greater fatigue and poorer performance.

During intense workouts, the body breaks down tryptophan, an amino acid. This process produces chemicals that can be detrimental to the brain. Normally, the body maintains a balance of these chemicals to protect the brain. But with extreme exercise, this balance is disrupted, resulting in the production of more harmful chemicals. This can exacerbate feelings of tiredness and impact brain function.

Scientists conducted experiments on mice to understand these effects. They discovered that excessive exercise lowered REV-ERB-α levels in mice, disrupting the balance of brain chemicals. The mice's muscles and brains were affected, demonstrating a clear connection between extreme exercise and its impact on the body and brain.

Interestingly, researchers found a potential solution. By administering a special drug to boost REV-ERB-α in mice, they were able to restore the balance of brain chemicals and mitigate the harmful effects of extreme exercise. This finding offers hope for future treatments to aid those who push their bodies too hard.

It's essential to recognize the importance of listening to your body. While exercise is beneficial, overexertion can have real effects on your internal clock and brain chemistry, ultimately making you feel worse rather than better.

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