Biliary tract cancers (BTCs), like intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma (eCCA), gallbladder cancer (GBC), and ampullary cancer, are tough to beat. Researchers looked at how death rates from these cancers changed over time. They checked out data from the World Healt
Advanced biliary tract cancer (BTC) is a tough nut to crack. Doctors often turn to second-line treatments like 5-fluorouracil (5FU) and liposomal irinotecan when first-line therapies fail. These drugs have shown promise in improving survival rates. But what if we could make them even more effective?
Scientists have made a significant discovery in the fight against cancer. They've created new compounds that can destroy specific forms of a protein called NSD2, which plays a role in cancer development. NSD2 comes in three versions due to a process called alternative splicing: long, short, and RE-I
King Charles has been dealing with something private besides his royal duties. He's been fighting cancer, and he's done it discreetly. A insider shared that the king wants to link up with others going through similar health struggles. His treatment is on track, and doctors anticipate it continuing f
Lung cancer screening rates in the US are alarmingly low, and the death rate is high. A team from a large urban health system, Jefferson Health, set out to change this. They pinpointed areas in Philadelphia with high lung cancer mortality rates using geocoded data. Then, they found primary care prac
Ever wondered how cancer cells stick around and grow? It's all about adhesion—how cells cling to each other and their surroundings. Certain proteins help cells stick together, keeping tissues healthy and balanced. But in cancers like chronic lymphocytic leukemia and mantle cell lymphoma, these prote
Pancreatic cancer, especially the type called pancreatic ductal adenocarcinoma (PDAC), is very dangerous. A medicine called paclitaxel, or PTX, is often given through a needle (intravenously) to treat this cancer. PTX can trigger a special type of cell death that helps the immune system fight cancer
Imagine tiny warriors, so small they can sneak into cancer cells undetected. These mini boosters are like secret agents, evading the body's usual defenses. Scientists are working hard to make these tools even better and safer for patients. It's a tough fight, but each small win matters. The journey
So, you've heard of calcium, right? It's not just for strong bones and teeth. In the world of cancer, high levels of calcium (Ca 2+ overload) inside cells can kill them off in various ways like apoptosis, pyroptosis, and more. This has become a big deal in cancer treatment. But it's not all smoot
Imagine you've just found out you have MGUS, a blood condition where proteins aren't acting like they should. Oh, and your doctor says your calcium levels are high? Don't panic just yet. A big study from Iceland, called iStopMM, dug into this exact situation. Out of 2, 546 people with MGUS, 191 had
