Mural Oncology plc, a biotech firm based in Waltham, is undergoing a major overhaul. The company has decided to halt the development of its primary cancer treatment, nemvaleukin. This move is part of a broader strategy to explore new directions for the firm. The decision to stop developing nemvaleukin is a significant one. It signals a shift in the company's focus a...
Cervical spinal cord stimulation is a technique that is often used to ease pain in the upper body. It is a type of neuromodulation that can be very effective. People often try it out for a week before deciding if they want a permanent implant. This is called a percutaneous trial. The stimulation usually happens in the thoracic area of the spine. But lately, the...
Eastern Europe is a hotspot for global clinical trials. Why? Because it's cost-effective. However, this comes with a catch. The region has some gaps in research oversight and a shortage of local experts in research ethics. This raises a big question: Are participants in these trials at risk of being taken advantage of or harmed? This is a serious concern that needs ...
Clinical trials are crucial for developing new treatments. However, some groups are often left out. This is a big problem because it means the treatments might not work as well for these groups. One such group is young adults. They are an important group to include because they will be the ones using these treatments in the future. So, it is vital to find ways to get...
Latinos with type 2 diabetes often face unique challenges. Many do not use intensive insulin management. This makes it hard to keep blood sugar levels in check. There is a need for better solutions. Some researchers looked into how real-time continuous glucose monitoring (RT-CGM) can help. They also explored how culturally tailored education can make a differenc...
IgA Nephropathy is a sneaky kidney condition. It is a bit like a silent intruder. It can affect both kids and adults. It shows up when a protein called IgA builds up in the kidneys. This can lead to serious kidney issues over time. Doctors are always trying to figure out who is at risk for this disease. They want to predict who will get worse. This helps them ...
Medical research often hinges on precise data. One crucial aspect is tracking when and if patients take their medicine. This has always been a challenge. In the past, researchers had to watch patients swallow pills, trust patients to report honestly, or count pills. These methods are far from perfect. They can be time-consuming, unreliable, or simply inconvenient. N...
Drug testing is a complex process. Sometimes, during trials, a drug may cause liver injury. This is a serious issue. The decision to give the drug again, known as a rechallenge, is tricky. There are no clear rules or guidelines to follow. This makes it hard for drug developers and experts to make informed choices. Most of the information available focuses on cases w...
Ivermectin has been a hot topic when it comes to treating COVID-19. But does it really work? A recent study looked at 19 different trials involving 1, 111 patients to find out. These trials compared Ivermectin to either a placebo or the usual standard of care. The study checked if Ivermectin helped with things like reducing deaths, speeding up recovery, or shortenin...
Huntington's disease is a challenging condition that affects movement, cognitive function, and mental health. Currently, there is no cure, so researchers are constantly exploring new methods to aid those affected. One intriguing approach is time-restricted eating, where individuals consume all their meals within a specific time frame each day. This method is similar ...