Triple-negative breast cancer (TNBC) is known for being hard to treat. It grows fast and doesn't respond well to most treatments. But there's a new treatment called sacituzumab govitecan (SG) that's giving hope to patients. In a big study called ASCENT, SG was compared to standard chemotherapy. The results were promising. Patients who took SG lived longer and their ...
Polymyalgia rheumatica is a condition that causes muscle pain and stiffness. It often affects older adults. Corticosteroids are usually the go-to treatment. But what happens when they don't work or cause too many side effects? That's where sarilumab comes in. It's a medication that's been approved for adults with this condition. The goal is to see how it affects pati...
Two treatments, sotorasib and adagrasib, have received approval in the USA and Europe for tackling advanced or metastatic non-small cell lung cancer. This type of cancer is marked by a specific mutation known as KRAS G12C. Since these treatments have not been directly compared in clinical trials, researchers turned to an alternative method. They used a technique call...
The way clinical trials are conducted is changing. More and more, the focus is on making them easier for patients to take part in. This shift is happening because of something called decentralized clinical trials or DCTs. These trials use modern technology to bring the clinical trial experience to the patient, rather than the other way around. In 2021, a major step ...
Bile duct cancers are a tough bunch to beat. They are tricky because they come in different forms and are hard to treat. For a long time, doctors have used a combo of gemcitabine and cisplatin to help patients feel better, even if it couldn't cure them. This was the go-to treatment for over ten years. But now, things are changing. Two big studies, TOPAZ-1 and KEYNOTE...
The idea of helping adults with borderline personality disorder (BPD) in a shorter time frame is gaining traction. A recent effort focused on a 12-week therapy program called Road Maps. This program is designed to serve as a middle ground in the care process for those diagnosed with BPD. The goal was to see if this program could make a real difference in a shorter pe...
Interstitial lung diseases are a group of conditions that cause scarring of the lungs. They can lead to sudden flare-ups, known as acute exacerbations. These flare-ups are particularly tough to manage in cases of idiopathic pulmonary fibrosis, a type of lung disease with an unknown cause. The outcome for patients experiencing these flare-ups is often grim, with a hig...
A recent study has shed light on the potential benefits of arimoclomol for individuals with Niemann-Pick disease type C (NPC). This study, known as NPC-002, was a 12-month trial. It was designed to be double-blind and randomized, with a placebo group for comparison. The main goal was to see how arimoclomol affected the progression of NPC. The results were measured us...
The world of clinical trials is changing fast. The focus is now on putting patients first. This means making sure they stay involved, follow the rules, and want to take part. To do this, more trials are using technology to reach patients where they are. This is called decentralized clinical trials or DCTs. But, is this really making things better for patients? The i...
The hunt for volunteers in liver disease studies is tough. Why? Because liver issues like cancer and scarring are complicated. Doctors need to check many details to find the right people. This is usually done by hand, which takes ages and can lead to mistakes. But there's hope on the horizon. Artificial intelligence, or AI, might be the answer. It can quickly go thro...