Brain organoids are tiny, simplified versions of a human brain grown in a lab. They are made from cells taken from people with a specific disease. These organoids help scientists understand how the disease affects the brain. One such disease is hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS). It is a rare and fatal brain disease that usually start...
Vimseltinib is a new drug that's making waves in the medical world. This drug is a small-molecule tyrosine kinase inhibitor, which means it can block certain enzymes that help cancer cells grow. It's specifically designed to target CSF1R, a protein that's overactive in tenosynovial giant cell tumors (TGCT). These tumors are rare and aggressive, often growing in soft ...
Knee injuries can be nasty, especially when they lead to post-traumatic osteoarthritis (PTOA). Imagine tearing a ligament and then dealing with severe joint damage. Scientists have found that a particular protein, colony stimulating factor 1 receptor (CSF1-R), is a key player in making things worse. To test this, they blocked this protein in mice that had similar inj...