Brain tumors, specifically glioma, are a big problem. They start in the support cells of the brain and can be very serious. Doctors have tried many treatments like surgery, drugs, and radiation, but these tumors often come back. So, what's going on? One key player in this is something called TGF-β. It's like a messenger in the body that tells cells what to do. In gl...
Scientists have found a way to make a powerful microscope work better with tiny drug particles in water. This microscope, called a scanning electron microscope (SEM), usually needs a vacuum to work, but it can also be used to look at things in liquid. The problem is, small drug particles and other organic materials don't stick well to the microscope's viewing area. T...
Drug development is expensive and risky. But what if there was a way to make it more appealing to investors? A new idea is on the table. It's about testing many drugs at once. This way, investors can put their money into a group of potential treatments instead of just one. Here's how it works. Investors chip in to cover part of the trial costs. In return, they get a...
Freeze-drying, or lyophilization, is a big deal in medicine. It's a process that makes drugs last longer, especially important ones like antibiotics. In fact, most of the antibiotics on the World Health Organization's Essential Medicines list are freeze-dried. This means they can be stored for a long time, ready to use when needed. But why is this important? Well, i...
In the world of drug development, keeping an eye on heart health is crucial. This is why experts track key heart signs like blood pressure, heart rate, and electrical activity in non-rodent animals. These signs are vital for understanding how safe a new drug might be. However, the way these signs are measured can make a big difference. Two main methods are used: ...
Prostate cancer is a big deal. It's a major health problem that hits a lot of people. The search for better treatments is always on. One exciting development is a unique drug combination. This mix includes a targeted radioactive material and a specific inhibitor. The radioactive material is called lutetium-177-PSMA. It's not your average radioactive stuff. Thi...
Cancer treatment has seen a major shift in recent years. The focus is now on precision oncology. This approach uses detailed information about a patient's tumor to create a personalized treatment plan. It is becoming a standard way to care for cancer patients. The cost of testing tumors has dropped significantly. This means more patients can access these advance...
Leishmaniasis is a sneaky parasite that causes a lot of trouble around the world. It is a big problem for global health, but we do not have many good treatments for it. Researchers are working on a new drug called DNDI-6174. This drug is special because it can be taken by mouth. It is still being tested, but it shows promise in fighting leishmaniasis. To test this d...
The pharmaceutical industry is undergoing a significant shift. Platform technologies are opening up new avenues for innovation in various medical fields. These technologies are not just about creating new drugs. They are about changing how drugs are developed, tested, and brought to market. Traditional methods of assessing the value of these technologies are falling ...
The world of genetic medicine is advancing rapidly, but not everyone is benefiting equally. People like Emily Kramer-Golinkoff, who has a rare form of cystic fibrosis, are often left behind. This disease, the most common fatal genetic condition in the U. S. , affects around 40, 000 Americans. However, Kramer-Golinkoff's specific genetic mutation means that the medica...