Liver problems caused by drugs are a big deal. They can lead to sudden liver failure, and they often show up only after a long time of taking the drug. This is a huge problem for people who make new drugs. They have to stop their work because it's too risky. But there is new hope. Scientists are us
In a significant development, the U. S. Food and Drug Administration (FDA) has given the green light to a new non-opioid painkiller. Called Journavx. This new medicine is a big deal because it's the first of its kind to target pain signals in the peripheral nervous system. This means it stops pain b
The COVID-19 pandemic, stretching over three years, has rocked the world. It's brought about significant changes across medicine, society, politics, and finance. One major challenge has been the virus's ability to mutate and evade our immune systems. The search is on for a stable target to develop v
Did you know that finding the perfect match between two things isn't always easy, especially when those things are tiny molecules and proteins? In the world of medicine, scientists are always looking for new ways to figure out how well these tiny partners stick together. One such method is called SP
Could we be entering an era where life-changing drugs like Wegovy and Zepbound become commonplace? That's what former U. S. Treasury Secretary Larry Summers suggested at the World Economic Forum in Davos, Switzerland. He believes we're in a time of incredible technological possibilities that are dri
Ever wondered how scientists keep an eye on cellular interactions? One fascinating approach involves using live cells as tiny detectors. Epidermal growth factor (EGF) plays a serious role in cancer development, so tracking its activity is crucial. Traditional lab methods have drawbacks, but now, the
Alzheimer's disease is a major challenge for modern medicine, as we still lack drugs that can truly stop or slow its progression. The number of people affected by Alzheimer's is expected to rise dramatically in the coming years. One big reason why finding new treatments is so hard is that many diffe
Ever wondered how cells communicate? One key player is something called cyclic AMP (cAMP). It's like a messenger that tells cells what to do. But sometimes, enzymes called phosphodiesterases (PDEs) break down cAMP, and that can cause trouble. Scientists have been trying to stop these PDEs, but their
Ever wondered how tiny compounds in nature can lead to big medical breakthroughs? Let's dive into the world of hexahydropyrrolo, a naturally occurring chemical that's been stirring up excitement among scientists. Synthesizing natural products, like hexahydropyrrolo, is like trying to recreate a comp
Imagine being able to target a specific part of a protein to fight leukemia with less side effects. That's what scientists are working on with a new drug called XY221. This drug, XY221, is special because it sticks to a tiny part of a protein called BRD4 BD2. This part is like a keyhole, and XY221 i
