Scientists have been on the hunt for better ways to fight cancer. They've found that a protein called HDAC1 plays a big role in how cancer grows. This protein is like a switch that can turn genes on and off. By targeting HDAC1, researchers hope to develop new drugs that can stop cancer in its tracks. To find the best drug candidates, scientists used a clever trick. ...
Cyanobacteria, often overlooked, are nature's tiny chemists. These blue-green algae pack a punch, producing a variety of biologically active compounds. These compounds play a big role in ecosystems and even hold promise for new medicines. However, tapping into this potential isn't easy. Researchers face several hurdles, from identifying the right compounds to scaling...
Lung cancer is a big deal. It's one of the most common and deadly cancers out there. Every year, about 2 million people get it, and 1. 8 million lose their lives because of it. And it's only getting worse. By 2050, experts think there could be 3. 8 million new cases. That's why finding it early and creating better treatments is so important. One of the coolest thing...
Epilepsy is a challenging condition, especially for those who don't respond to standard medications. This is known as drug-resistant epilepsy, and it's a significant issue that needs new solutions. Scientists have been investigating a protein called PHGDH. This protein is found in brain cells and plays a crucial role in producing essential compounds like serine and ...
Malaria is a big problem, especially in Africa. It's caused by a tiny creature called Plasmodium falciparum. This creature needs special proteins to grow and survive. One of these proteins is called PfPK5. If scientists can block PfPK5, they might be able to stop malaria. Some plants in Nigeria are known to fight malaria. Scientists looked at 196 special parts of th...
Phenolic compounds found in plants have shown great promise in tackling chronic health issues. These compounds are known for their wide-ranging health benefits and low toxicity. However, treating inflammation often requires more than just one approach. This is because inflammation is complex and involves multiple processes in the body. Researchers have been looking ...
The world of drug discovery is getting a high-tech makeover. A new method called PoLiGenX is shaking things up. It uses a clever trick called latent-conditioned, target-aware equivariant diffusion. This fancy term means it can create new molecules that fit perfectly into specific parts of proteins. The process is smart. It looks at existing molecules in a protei...
Breast cancer is a big problem for women all around the world. It is the leading cause of death for women. This is why finding new ways to treat it is so important. One exciting approach combines smart technology with biology. The idea is to use advanced computing methods to improve how well certain medicines work. These medicines target a specific part of cells...
The quest for new medicines is a marathon, not a sprint. It is a costly and time-consuming process with a high failure rate. Scientists are always on the hunt for new methods to make drug discovery more efficient. One promising approach is de novo drug design. This method has gained traction in the past decade because it can explore vast chemical spaces and create hi...
Cancer is a major health issue worldwide, largely due to the rapid spread of abnormal cells. These cells often form tumors, like carcinomas, which come from epithelial cells growing out of control. Tumors release growth factors such as FGF and VEGF. These factors help new blood vessels form, a process called angiogenesis. This process is crucial for tumor growth and ...