Cancer treatment has seen a major boost with the introduction of allogeneic cell-based therapies. These treatments, especially CAR-T cell therapy, are a big deal because they can be made in large quantities and are consistent. However, there is a significant hurdle: graft-versus-host disease (GvHD). This occurs when the transplanted cells attack the patient's body. R...

A recent study explored the use of post-transplant high-dose cyclophosphamide (PTCy) in haematopoietic cell transplantation (HCT) from mismatched unrelated donors (MMUD) in patients with acute myeloid malignancies. The research focused on whether PTCy, along with a calcineurine inhibitor and mycophenolate mofetil, could improve outcomes and reduce the incidence ...